Pneumocandins from Zalerion arboricola. III. Structure elucidation.
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چکیده
منابع مشابه
Pneumocandins from Zalerion arboricola. III. Structure elucidation.
Pneumocandin B0 (6) and six related lipopeptides are antifungal and anti-Pneumocystis carinii agents from mutants of Zalerion arboricola, whose structures were determined mainly on the basis of spectroscopic analysis. They belong, along with pneumocandin A0 (L-671,329) previously isolated from these laboratories, to the echinocandin class of antifungal agents. The product from base-catalyzed ri...
متن کاملFROMZalerion arboricola V. GLUTAMIC ACID- AND LEUCINE- DERIVED AMINO ACIDS IN PNEUMOCANDIN Ao (L-671,329) AND DISTINCT ORIGINS OF THE SUBSTITUTED PROLINE RESIDUES IN PNEUMOCANDINS Ao AND Bo
The accompanying papers1 ~3) describe a family of pneumocandins produced by the helicosporous fungus, Zalerion arboricola. The pneumocandins are acylated cyclic hexapeptides belonging to the echinocandin group of antifungal antibiotics.4* We have initiated a study of the biosynthesis of pneumocandin Ao (formerly L-671,329) which is the most prominent pneumocandin in the fermentation. It contain...
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A unique lipopeptide antimycotic, termed cryptocandin, is described from Cryptosporiopsis cf. quercina, an endophytic fungus. Cryptocandin, with a molecular mass of 1079 Da, contains equimolar amounts of 3,4-dihydroxyhomotyrosine, 4-hydroxyproline, threonine, glutamine, 3-hydroxy-4-hydroxymethylproline, 4,5-dihydroxyornithine and palmitic acid. Cryptocandin is chemically related to well-known a...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1992
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.45.1875